On 13 December 2014, Spence beat Javier Castro by TKO in the 5th round at the MGM Grand Hotel and Casino in Las Vegas. Spence was taken the distance and won a shutout unanimous decision. Spence made his Showtime television debut on 27 June 2014 at the Hard Rock Hotel in Las Vegas in a 10-round fight against Ronald Cruz. By the end of 2013, Spence had won all of his 10 professional fights, 8 of them by way of knockout. The fight was rather one-sided, with all judges scoring the fight 79–73 in favor of Spence. He was taken the distance in an eight-round bout in October by Emmanuel Lartei Lartey.

Spence fought eight times in 2013, being victorious in all of them, winning six inside the distance. In December 2012, Spence knocked out Richard Andrews at the Sports Arena in Los Angeles, California, which was part of undercard for Amir Khan's comeback fight against Carlos Molina. Spence knocked Garcia down and out in the 3rd round. On 9 November 2012, a 22 year old Spence made his professional debut at the Fantasy Springs Casino in Indio, California in a scheduled 4 round bout against 19 year old Jonathan Garcia. He ended his amateur career with a record of 135–12. Spence lost in the quarter finals of the 2012 London Olympics to Andrey Zamkovoy and turned professional shortly afterwards. Spence reached the quarter-finals at the 2011 World Championships, losing to Serik Sapiyev. National Golden Gloves, and also won three consecutive national amateur welterweight championships from 2009 to 2011, all in the welterweight division. He is also ranked as the world's best active welterweight by The Ring, and TBRB, and second by BoxRec, and ESPN. Īs of May 2022, Spence is ranked as the world's third best active boxer, pound for pound, by ESPN, fourth by The Ring magazine, Boxing Writers Association of America and TBRB, and fifth by BoxRec. In 2015, Spence was named Prospect of the Year by ESPN. at the 2012 Olympics, where he reached the quarter-finals. As an amateur, in the welterweight division, he won three consecutive United States national championships and represented the U.S. He is a former unified champion in the welterweight division, having held the World Boxing Association (WBA) ( Super version), World Boxing Council (WBC), and International Boxing Federation (IBF) titles between 2017 and July 2023. (born March 3, 1990) is an American professional boxer.

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